Royzen Lab | News
Maksim (Max) Royzen research into applications of bio-orthogonal chemistry for in vivo imaging and RNA synthesis.
Maksim Royzen, Max Royzen, RNA imaging, live cell imaging, TCO, tetrazine, trans-cyclooctene, UAlbany Chemistry, RNA Institute, bio-orthogonal, bioorthogonal, MNP, nanoparticle, HMT, hydrogel, soft tissue sarcoma, STS, doxorubicin, dox-TCO, RNA-protein interactions, PRE, paramagnetic NMR, RNA synthesis, drug delivery
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NEWS

13 JUNE 2017

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A collaborative project between Royzen and Yigit Labs was just accepted for publication by Chemical Science. This work describes delivery and controlled in-cell activation of siRNA using iron oxide magnetic nanoparticles and bio-orthogonal chemistry. Congratulations to everyone involved in this work!

3 JANUARY 2017

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A new graduate student, Aly Hoy, joined the lab. Welcome!

25 AUGUST 2016

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Max is to present at the Bioorthogonal Chemistry symposium at ACS Northeast Regional Meeting in Binghamton, New York, October 5-6, 2016.

15 JUNE 2016

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A new graduate student,
Angel Thompson, joined our group.

15 MARCH 2017

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Leah’s second paper was just accepted for publication by Inorganic Chemistry. The paper reports a Cu(II)-based paramagnetic probe to investigate binding of HIV-1 protein, NCp7, to RNA using PRE NMR. This work was also done in collaboration with Shekhtman Lab, Chen Lab and the RNA Institute.

3 JANUARY 2017

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A new graduate student, Muhan He joined the lab. She will be co-mentored with Prof. Yigit and work on collaborative projects.

21 AUGUST 2016

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Edgar Agustin presents a talk at the 2016 Annual ACS Meeting in Philadelphia (ORGN 650), and Leah Seebald presents a poster (BIOL 203).

01 FEBRUARY 2016

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New paper, In situ activation of a doxorubicin prodrug using image-capable nanoparticles, describing activation of a doxorubicin pro-drug inside of live breast cancer cells using magnetic nanoparticles was just published by Chem Comm. Congratulations to everyone involved in this work!

8 MARCH 2017

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Leah’s paper was just accepted for publication by Journal of Inorganic Biochemistry. The paper reports a Cobalt-based paramagnetic probe that has been explored to study RNA-protein interactions using PRE NMR. This work was done in collaboration with Shekhtman Lab, Chen Lab and the RNA Institute at SUNY, Albany.

22 DECEMBER 2016

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Our collaborative work with Pluth Lab was just accepted for publication by Chem Comm. The paper describes a bio-orthogonal chemistry-based approach for in situ generation of carbonyl sulfide (COS) and its subsequent conversion to hydrogen sulfide (H2S) by carbonic anhydrase.

13 JULY 2016

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New paper, In vivo bioorthogonal chemistry enables local hydrogel and systemic pro-drug to treat soft tissue sarcoma describing in vivo activation of a doxorubicin pro-drug to treat soft tissue sarcoma finally found its home at ACS Central Science. The first publication that came out of our industrial collaboration with Shasqi, Inc. Many more to come…

12 JANUARY 2016

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New paper, A fast click-slow release strategy towards HPLC-free synthesis of RNA, describing HPLC-free purification of synthetic RNA just came out in Chem Comm. Congratulations to everyone involved in this work!