Publications
Maksim (Max) Royzen research into applications of bio-orthogonal chemistry for in vivo imaging and RNA synthesis.
Maksim Royzen, Max Royzen, RNA imaging, live cell imaging, TCO, tetrazine, trans-cyclooctene, UAlbany Chemistry, RNA Institute, bio-orthogonal, bioorthogonal, MNP, nanoparticle, HMT, hydrogel, soft tissue sarcoma, STS, doxorubicin, dox-TCO, RNA-protein interactions, PRE, paramagnetic NMR, RNA synthesis, drug delivery
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PUBLICATIONS

Wu, X.; Wu, K.; Gaye, F.; Royzen, M. Bond-breaking bio-orthogonal chemistry efficiently uncages fluorescent and therapeutic compounds under physiological conditions.  Org. Lett. 2020, 22, 6041-6044. [10.1021/acs.orglett.0c02129]

Czuban, M.; Kulka, M, W.; Wang, L.; Koliszak, A.; Achazi, K.; Schlaich, C.; Donskyi, I. S.; Di Luka, M.; Mejia Oneto, J. M.; Royzen, M.; Haag, R.; , Trampuz, A. Titanium coating with mussel-inspired polymer and bio-orthogonal chemistry enhances antimicrobial activity against S. aureusMat. Sci. Eng. C 2020, 116, 111109. [10.1016/j.msec.2020111109]

He, M.; Nadhu, N.; Uyar, B. T.; Royzen, M.; Yigit, M. Small molecule-induced DNA hydrogel with encapsulation and release properties.  Chem. Comm. 2020, 56, 7313-7316. [10.1039/D0CC03439H]

Marcias-Contreras, M.; He, H.; Little, K. N.; Lee, J. P.; Campbell, R. P.; Royzen, M. Zhu, L. SNAP/CLIP-Tags and Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC)/Inverse Electron Demand Diels-Alder (IEDDA) for Intracellular Orthogonal/Biorthogonal Labeling.  Bioconj. Chem. 202031, 1370-1381. [10.1021/acs.bioconjchem.oc00107]

Uyar, T. B.; Wu, K.; He,  M.; Khan, I.; Royzen, M.; Yigit, M. Switchable fluorescence of doxorubicin for label-free imaging of bioorthogonal drug release. ChemMedChem, 2020, 15, 988-994. [10.1002/cmdc.202000065]

Handbook of In Vivo Chemistry in Mice: From Lab to Living System. Chapter 9: In Vivo Bioconjugation Using Bio-orthogonal Chemistry. (pp. 249-279) Wiley, 2020. [10.1002/9783527344406]

Kenderdine, T.; Nemati, R.; Baker, A.; Palmer, M.; Ujma, J.; Fitzgibbon, M.; Deng, L.; Royzen, M.; Langridge, J.; Fabris, D.  High-Resolution Ion Mobility Spectrometry-Mass Spectrometry of Isomeric/Isobaric Ribonucleotide Variants. J. Mass Spec. 202055, e4465. [10.1002/jms.4465]

pubs_Fabris-2019

Dai, Y.; Weng, J.; George, J.; Chen, H.; Lin, Q.; Wang, J.; Royzen, M.; Zhang, Q. Three-Component Protein Modification Using Mercaptobenzaldehyde Derivatives. Org. Lett. 2019, 21, 3828-3833. [10.1021/acs.orglett.9b01294]

pubs_quiang_2019-paper.jpg

Wu, K.; He, M.; Asare Okai, P. N.; Lin, Q.; Fuchs, G.; Royzen, M. Bio-orthogonal chemistry-based method for fluorescent labelling of ribosomal RNA in live mammalian cells. Chem. Commun. 2019, 55, 10456-10459. [10.1039/C9CC05346H]

Czuban, M.; Srinivasan, S.; Yee, N. A.; Agustin, E.; Koliszak, A.; Miller, E.; Khan, I.; Qunones, I.; Noory, H.; Motola, C.; Volkmer, R.; Di Luka, M.; Trampuz, A.; Royzen, M.; Mejia Oneto, J. M. Bio-orthogonal chemistry and reloadable biomaterial enable local activation of antibiotic prodrugs and enhance treatments against Staphylococcus aureus infections. ACS Cent. Sci., 2018, 4, 1624-1632. [10.1021/acscentsci.8boo344]

Robertson, N. M.; Yang, Y.; Khan, I.; LaMantia, V. E.; Royzen, M.; Yigit, M. Single-trigger dual-responsive nanoparticles for controllable and sequential prodrug activation. Nanoscale, 2017, 9, 10020-10030. [10.1039/C7NR04138A]

Khan, I.; Seebald, L. M.; Robertson, N.; Yigit, M. V.; Royzen, M. Controlled in-cell activation of RNA therapeutics using bond-cleaving bio-orthogonal chemistry. Chem. Sci. 2017, 8, 5705-5712. [10.1039/C7SC01380A]

Seebald, L. M.; DeMott, C. M.; Ranganathan, S.; Asare Okai, P. N.; Glazunova, A.; Chen, A.; Shekhtman, A.; Royzen, M. Cu(II)-based paramagnetic probe to study RNA-protein interactions by NMR. Inorg. Chem. 2017, 56, 3773-3780. [10.1021/acs.inorgchem.6b02286]

Seebald, L. M.; DeMott, C. M.; Ranganathan, S.; Asare Okai, P. N.; Glazunova, A.; Chen, A.; Shekhtman, A.; Royzen, M. Cobalt-based paramagnetic probe to study RNA-protein interactions by NMR. J. Inorg. Biochem. 2017, 170, 202-208. [10.1016/j.jinorgbio.2017.02.024]

Steiger, A. K.; Yang, Y.; Royzen, M.; Pluth, M. D. Bio-orthogonal “click-and-release” donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S). Chem. Commun. 2017, 53, 1378-1380. [10.1039/C6CC09547J]

Mejia, J. M. O.; Khan, I.; Seebald, L.; Royzen, M. In vivo bioorthogonal chemistry enables local hydrogel and systemic pro-drug to treat soft tissue sarcoma. ACS Cent. Sci. 2016, 2, 476-482. [10.1021/acscentsci.6b00150]

Khan, I.; Agris, P. F.; Yigit, M. V.; Royzen, M. In situ activation of a doxorubicin prodrug using image-capable nanoparticles. Chem. Commun. 2016, 52, 6174-6177. [10.1039/C6CC01024E]

Agustin, E.; Asare Okai, P. N.; Khan, I.; Miller, M. R.; Wang, R.; Sheng, J.; Royzen, M. A fast click-slow release strategy towards HPLC-free synthesis of RNA. Chem. Commun. 2016, 52, 1405-1408. [10.1039/C5CC05392G]

Asare Okai, P. N.; Agustin, E.; Royzen, M. Site-specific fluorescence labeling of RNA using bio-orthogonal reaction of trans-cyclooctene and tetrazine. Chem. Commun. 2014, 50, 7844-7847. [10.1039/C4CC02435D]

PUBLICATIONS PRIOR TO UNIVERSITY AT ALBANY

Song, Y.; Suntharalingam, K.; Yeung, J.; Royzen, M.; Lippard, S. J. Synthesis and characterization of Pt(IV) fluorescein conjugates to investigate Pt(IV) intracellular transformations. Bioconj. Chem. 2013, 24, 1733-1740.

Royzen, M.; Canary, J.W.  Structural parameters in 8-hydroxyquinoline tripodal ligand complexes in zinc(II) affect fluorescence quantum yield,” Polyhedron, 2012, 58, 85-91.

Royzen, M.; Wilson, J. J.; Lippard, S. J. Physical and structural properties of [Cu(BOT1)Cl]Cl, a fluorescent imaging probe for HNO. J. Inorg. Biochem. 2013, 118, 162-170.

Xu, F.; Chung, J. Y. L.; Moore, J. C.; Liu, Z.; Yoshikawa, N.; Hoerrner, R. S.; Lee, J.; Royzen, M.; Cleator, E.; Gibson, A. G.; Dunn, R.; Maloney, K. M.; Alam, M.; Goodyear, A.; Lynch, J.; Yasuda, N.; Devine, P. N. Asymmetric synthesis of cis-2,5-disubstituted pyrrolidine, the core scaffold of beta-AR agonists. J. Org. Lett. 2013, 15, 1342-1345.

Filipovic, M. R.; Miljkovic, J. L.; Nauser, T.; Royzen, M.; Klos, K.; Shubina, T.; Koppenol, W. H.; Lippard, S. J.; Ivanović-Burmazović, I. J. Am. Chem. Soc. 2012, 134, 12016-12027.
A Science and Technology, News of The Week describing this work appeared in Chemical and Engineering News 2012, 80 (28), 5.

Gruppi, F.; Liang, J.; Bartelle, B. B.; Royzen, M.; Turnbull, D. H.; Canary, J. Supramolecular metal displacement allows on-fluorescence analysis of manganese(II) in living cells. Chem. Commun. 2012, 48, 10778-10780.

Royzen, M.; Taylor, M. T.; DeAngelis, A.; Fox, J. M. Total synthesis of hyacinthacine A2: stereocontrolled 5-aza-cyclooctene photoisomerization and transannular hydroamination with planar-to-point chirality transfer. Chem. Sci. 2011, 2, 2162-2165.

Blackman, M. L.; Royzen, M.; Fox, J. M. Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J. Am. Chem. So. 2008, 130, 13518-13519.
A Science and Technology Concentrate describing this work appeared in Chemical and Engineering News 2008, 86 (40), 8.

Royzen, M.; Yap, G. P. A.; Fox, J. M. A photochemical synthesis of functionalized trans-cyclooctenes driven by metal complexation. J. Am. Chem. Soc. 2008, 130, 3760-3761.

Royzen, M.; Durandin, A.; Young, V. G.; Geacintov, N. E.; Canary, J. W. A sensitive probe for the detection of Zn(II) by time-resolved fluorescence. J. Am. Chem. Soc. 2006, 128, 3854-3855.

Royzen, M.; Dai, Z.; Canary, J. W. Ratiometric displacement approach to Cu(II) sensing by fluorescence. J. Am. Chem. Soc. 2005, 127, 1612-1613.

Choe, Y. H.; Conover, C. D.; Wu, D.; Royzen, M.; Greenwald, R. B. Anticancer drug delivery systems: N-acyl poly(ethylene glycol) prodrugs of ara-C. Efficacy in solid tumors. J. Control Release. 2002, 79, 41-53.

Choe, Y. H.; Conover, C. D.; Wu, D.; Royzen, M.; Gervacio, Y.; Borowski, V.; Mehlig, M. Anticancer drug delivery systems: N-acyl poly(ethylene glycol) prodrugs of ara-C: II. Efficacy in ascites and solid tumors. J. Control Release. 2002, 79, 55-70.

Greenwald, R. B.; Choe, Y. H.; Conover, C. D.; Shum, K.; Wu, D.; Royzen, M. Drug delivery systems based on trimethyl lock lactonization: poly(ethylene glycol) prodrugs of amino-containing compounds. J. Med. Chem.  2000, 43, 475-487.